Moderated by the Anchor Institution Task Force, this special issue of the Journal of Higher Education Outreach and Engagement details the successes and challenges of anchor institution–community partnerships and discusses what it takes to create and sustain effective collaborative strategies. Topics covered include: what it means to be an anchor institution, how to build coalitions and collective expertise, engaging the arts, how colleges can support entrepreneurial ecosystems, the role of higher education in Promise Neighborhoods, and the role of service-learning in promoting anchor institution work. Detailed case studies are presented from Syracuse, Widener, Miami Dade College, Tulsa Community College, Lehigh, University of Michigan, and University of Tennessee.